Journal
CHEMISTRY OF MATERIALS
Volume 21, Issue 24, Pages 5819-5825Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm902379x
Keywords
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Funding
- Creative Research Initiative Program [0417-20090011]
- Korea Ministry of Education, Science and Technology (MEST)
- Intramural Research Program of KIST
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Novel fluorescent bionanoparticles (GC3CNx) were prepared by self-assembly of biopolymeric amphiphiles that are composed of hydrophilic glycol chitosan (GC) as a biopolymeric backbone and a dipolar tricyanostilbene derivative (3CN) as a densely conjugated hydrophobic pendant. In the molecular design of 3CN, a dipolar electronic structure was introduced to spectrally shift the aggregation-induced enhanced fluorescence of the a-cyanostilbene skeleton toward the near-infrared (NIR) useful for bioimaging. It has been Found that the fluorescence of GC3CNx nanoparticles is red-shifted and intensified by increasing the 3CN content in the biopolymeric amphiphile. By cellular and in vivo imaging experiments, we demonstrate that GC3CNx nanoparticles have great potential for NIR bioimaging, with attractive properties including enhanced fluorescence signal, efficient cellular uptake, and better spectral coincidence with the in vivo transparent window.
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