Journal
CHEMISTRY OF MATERIALS
Volume 20, Issue 19, Pages 6087-6094Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm801020s
Keywords
-
Funding
- Particle Engineering Research Center (PERC) at the University of Florida
- National Science Foundation (NSF) [EEC-94-02989]
- NSF-NIRT [EEC-0506560]
- National Institutes of Health [1-P20-RR020654-01, RO11-111-75258, RO11-11-7 670]
- James & Esther King Biomedical Research Program [06NIR-05]
- Patricia Aclarns Cancer Nanotechnology Research Fund
- PERC
Ask authors/readers for more resources
In this report the synthesis, characterization, and financial evaluation of a multimodal nanoparticulate Contrast agent for noninvasive imaging through both magnetic resonance imaging, (MRI) and photoacoustic tomography (PAT) is presented. The nanoparticles described herein enable high resolution and highly sensitive three-dimensional diagnostic imaging through the synergistic coupling of MRI and PAT capabilities. Gadoliniurn (15d)-doped gold-speckled silica (GSS) nanoparticles. ranging from 50 to 200 Jim. have been prepared in a simple one-pot synthesis using nonionic microemulsions. The photoacoustic signal is generated from a nonuniform, discontinuous gold nanodomains speckled across the silica surface, whereas the MR contrast is provided through Gd incorporated in the silica matrix. The presence of a discontinuous speckled Surface, as opposed to a Continuous gold shell, allows sufficient bulk water exchange with the Gd ions to generate a strong MR contrast. The dual imaging capabilities of the particles have been demonstrated through in silicio and in vitro methods. The described particles also have the capacity for therapeutic
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available