Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 49, Issue 9, Pages 1378-1383Publisher
SPRINGER
DOI: 10.1007/s10593-013-1388-9
Keywords
2,1-benzothiazines; esters; acylation; analgesic activity; heterocyclization
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A preparative method for the synthesis of a series of 1-R-4-hydroxy-2,2-dioxo-1H-2 lambda(6),1-benzothiazine-3-carboxylates has been developed. The special features of the steric structure for compounds of this class have been studied on the example of the 1-N-methyl derivative. Results of studying the analgesic properties of the substances obtained are given.
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