4.1 Article

4-HYDROXY-2-QUINOLONES 144. ALKYL-, ARYLALKYL-, AND ARYLAMIDES OF 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-a]PYRIMIDINE-3-CARBOXYLIC ACID AND THEIR DIURETIC PROPERTIES

Journal

CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 44, Issue 5, Pages 565-575

Publisher

SPRINGER
DOI: 10.1007/s10593-008-0076-7

Keywords

amides; 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylic acids; tricarbonylmethane heterocyclic derivatives; diuretic activity; X-ray structural analysis

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Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.

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