Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 44, Issue 5, Pages 565-575Publisher
SPRINGER
DOI: 10.1007/s10593-008-0076-7
Keywords
amides; 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylic acids; tricarbonylmethane heterocyclic derivatives; diuretic activity; X-ray structural analysis
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Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.
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