Journal
CHEMISTRY LETTERS
Volume 43, Issue 4, Pages 556-558Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.131199
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [12J07172] Funding Source: KAKEN
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The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford alpha-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.
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