Journal
CHEMISTRY LETTERS
Volume 43, Issue 3, Pages 287-289Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.130960
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21221009, 24310160, 25750386]
- MEXT
- Grants-in-Aid for Scientific Research [25750386] Funding Source: KAKEN
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A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2D NMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.
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