4.3 Article

Cobalt-catalyzed Branched-selective Addition of Aromatic Ketimines to Styrenes under Room-temperature Conditions

Journal

CHEMISTRY LETTERS
Volume 42, Issue 10, Pages 1140-1142

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.130508

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Funding

  1. National Research Foundation, Singapore [NRF-RF-2009-05]
  2. Nanyang Technological University
  3. JST, CREST

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An improved cobalt-based catalytic system has been developed for the branched-selective addition of aromatic ketimines to styrenes. With an appropriate combination of triarylphosphine and the Grignard reagent, the reaction takes place smoothly at room temperature to afford 1,1-diarylethane derivatives with high regioselectivity.

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