Journal
CHEMISTRY LETTERS
Volume 41, Issue 10, Pages 1334-1336Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2012.1334
Keywords
-
Categories
Funding
- ParaCo Technology Ltd.
- AgResearch Ltd. (New Zealand)
Ask authors/readers for more resources
Nanostructured silica-lipid hybrid (SLH) microparticles, which are fabricated based on Pickering emulsion templates, are reported to enhance the encapsulation efficiency of a weak base anthelmintic, albendazole (ABZ). ABZ exhibits poor solubility in aqueous solutions and in commonly used pharmaceutical surfactants and oils. The encapsulation of ABZ-SLH in a supersaturated but noncrystalline form was shown to enhance its dissolution kinetics (up to tenfold) in simulated gastric fluids, regardless of the presence of sink conditions that were representative of the influence of food intake.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available