4.3 Article

Mild Synthesis of Furans with a Quaternary Carbon Substituent at the 2-Position

Journal

CHEMISTRY LETTERS
Volume 41, Issue 12, Pages 1586-1587

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2012.1586

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Funding

  1. Grants-in-Aid for Scientific Research [24550055] Funding Source: KAKEN

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The reaction of cis-4-oxopent-2-enal with beta-carbonyl compounds in the presence of weak acids such as hexafluoroisopropyl alcohol was found to give furans with a quaternary carbon substituent at the 2-positon at room temperature or below. Reactivity was dependent on the identity of the substrates.

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