4.3 Article

Synergistic Cell Killing by Magnetic and Photoirradiation Effects of Neck-structured α-Fe2O3 against Cancer (HeLa) Cells

Journal

CHEMISTRY LETTERS
Volume 40, Issue 7, Pages 773-775

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2011.773

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Funding

  1. Japan Society for the Promotion of Science (JSPS) [19360367, 22.00083]
  2. Grants-in-Aid for Scientific Research [10F00083, 23655204] Funding Source: KAKEN

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Nanosized neck-structured alpha-Fe2O3 nanoparticles were prepared successfully from iron(II) chloride tetrahydrate solely by hydrothermal method. FE-SEM and TEM studies revealed a unique necked structure with a particle size of ca. 50-60 nm. The synthesized nanomaterials showed excellent colloidal stability and magnetization ability. Finally, the as-prepared alpha-Fe2O3 nanoparticle suspensions showed almost 100% cancer cell killing by the significant temperature increment when an AC (alternating current) magnetic field and photoirradiation were applied at a concentration of 80 mu g mL(-1) MEM (minimum essential medium).

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