4.3 Article

Preparation of Nanoaggregates through Self-assembly of Amphiphilic Polyrotaxane Composed of PLLA-PEG-PLLA Triblock Copolymer and α-Cyclodextrins

Journal

CHEMISTRY LETTERS
Volume 39, Issue 3, Pages 250-251

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2010.250

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Funding

  1. MEXT, Japan [20034055, 19300170]
  2. Grants-in-Aid for Scientific Research [20034055, 19300170] Funding Source: KAKEN

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An amphiphilic polyrotaxane (PRX) composed of biodegradable triblock copolymer of poly(ethylene glycol) (PEG) and poly(L-lactide) (PLLA), PLLA PEG PLLA, and many alpha-cyclodextrins (alpha-CD) threaded on the triblock copolymer was successfully synthesized. The PRX was found to be self-assembled into vesicle-like water-soluble nanoaggregates in an aqueous solution.

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