Journal
CHEMISTRY LETTERS
Volume 38, Issue 11, Pages 1114-1115Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2009.1114
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Funding
- JST
- Ministry of Education, Culture, Sports, Science and Technology [20240047, 18GS0421]
- JSPS [20-4657]
- Grants-in-Aid for Scientific Research [20240047] Funding Source: KAKEN
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A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.
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