4.3 Article

Ni0-catalyzed Direct Amination of Anisoles Involving the Cleavage of Carbon-Oxygen Bonds

Journal

CHEMISTRY LETTERS
Volume 38, Issue 7, Pages 710-711

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2009.710

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Funding

  1. MEXT, Japan

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Ni-0-catalyzed cross-coupling of aryl methyl ethers with amines is described. The use of an N-heterocyclic carbene as a ligand and NaOt-Bu as a base promotes the amination of anisole derivatives via the cleavage of normally unreactive aryl carbon-oxygen bonds.

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