Direct asymmetric aminoxylation reaction catalyzed by axially chiral amino acids

Binaphthyl-based amino acids were prepared and applied for the direct asymmetric aminoxylation of aldehydes with nitrosobenzene. The reaction catalyzed by (S)-1e proceeded smoothly to give the aminoxylated product in good yield and enantioselectivity. This method represents a rare example of the direct asymmetric aminoxylation by a non-proline-type catalyst.