Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 165, Issue 7, Pages 737-744Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2012.08.002
Keywords
Liquid-liquid coexistence; Curvature; Domain size; Cholesterol-rich
Categories
Funding
- SECyT-UNC
- CONICET
- FONCYT, Argentina [BID 0770]
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The line tension (X) in biphasic membranes has been determined in monolayers and bilayers using a variety of techniques. In this work we present a novel approach to the determination of A in monolayers with liquid/liquid phase coexistence, overcoming several of the drawbacks of current techniques. Using our method, we determined the line tension of liquid/liquid phases in binary mixtures of different lipids and a molecule similar to cholesterol but less oxidizable. We analyzed the effect of the hydrocarbon chain length and the polar head-group of the non-sterol lipid and found the latter to exert much more influence than the former. The presence of PE led to high X values, PG to low values and PS and PC to intermediate values. The line tension showed a strong correlation with the critical packing parameter of the phospholipid. The spontaneous curvature displayed by the phases constituted by a particular lipid appears to be an important parameter for determining the line tension in mixed films. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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