Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 165, Issue 2, Pages 232-237Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2012.01.003
Keywords
Lipid monolayer; Phase coexistence; Domain shape; Nucleation; Monolayer topography
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Funding
- SECyT-UNC
- CONICET
- FONCYT, Argentina [BID 1728/OC-AR PICT 1381, 0770, PAE 22642]
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The phase diagram of mixed monolayers composed of dimyristoyl phosphatidylcholine (DMPC) and stearic acid (SA) on different subphases was previously reported. It was observed that on acid subphases, liquid-condensed domains with shapes that depend on the SA proportion are formed. For mixtures with 40-45 mole% of SA, the domain shape changes from flower-like to circular domains. In this work, we carried out a detailed study of the driving force for the shape change. We find that it is related to the domain density which, in turn, is driven by the domain nucleation process and thus by oversaturation of the system leading to phase segregation. This could be a way of self-regulating the local electrostatics and mechanical properties in membrane surfaces with segregated phase domains. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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