Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 164, Issue 6, Pages 556-562Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2011.06.007
Keywords
Mass spectrometry; Glycerophospholipids; ESI-MS/MS; Polyglycerophospholipids; Chromatography; Shotgun-MS
Categories
Ask authors/readers for more resources
Polyglycerophospholipids (PGPLs) such as bismonoacylglycerophosphate (BMP) and cardiolipin are important membrane phospholipid species for the maintenance of membrane integrity. While BMP serves as membrane curvature regulator in multivesicular bodies for efficient lysosomal enzyme function, cardiolipin stabilizes the electron transfer complex in the inner mitochondrial membrane, which is crucial for physiological ATP production. Beside their membrane modulatory functions PGPLs play an important role in various signaling events. Although a number of disease associations were found for PGPL species, detailed information about their molecular role still remains unknown. This article reviews the known biological functions of PGPLs and the existing mass spectrometric methods. We discuss the different analytical strategies and how ESI-MS/MS can expand our understanding of PGPL homeostasis. (C) 2011 Published by Elsevier Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available