Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 163, Issue 6, Pages 449-459Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2010.03.002
Keywords
Lipidomics; Enveloped virus; Membrane; Receptor; Glycolipid; Lipid-protein interactions
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Funding
- Singapore National Research Foundation under CRP [2007-04]
- Biomedical Research Council of Singapore [R-183-000-211-305]
- National Medical Research Council [R-183-000-224-213]
- SystemsX.ch
- National University of Singapore (NUS)
- NUS Graduate School for Integrative Sciences and Engineering (NGS)
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Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are intracellular parasites that acquire lipid envelopes from their host cells. Success of replication is intimately linked to their ability to hijack host cell mechanisms, particularly those related to membrane dynamics and lipid metabolism. Despite recent progress, our knowledge of lipid mediated virus-host interactions remains highly incomplete. In addition, diverse experimental systems are used to study different stages of virus replication thus complicating comparisons. This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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