Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 163, Issue 8, Pages 787-793Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2010.09.004
Keywords
Liposome mechanics; Evans model; Aspiration; DOPC:DOPS
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Funding
- National Science Foundation
- Keck Foundation Institute of Attofluidics at Drexel University
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Quantification of the mechanical properties of liposomes is critical in helping to predict their behavior during various applications such as targeted drug delivery, response to mechanical characterization or their interactions with isolated cytoskeletal elements. A numerical implementation of the Evans aspiration technique, and an image processing algorithm for measuring deformation of spherical DOPC:DOPS liposomes is presented. Liposomes were aspirated to pressures of -10 mmHg (similar to-1300 Pa). The area expansion and Young's moduli of the liposomes were found to be 0.067 N m(-1) (67 +/- 4 dyn/cm) and 15 +/- 1 MPa, (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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