Journal
CHEMISTRY & BIOLOGY
Volume 21, Issue 2, Pages 257-263Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2013.12.005
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Funding
- National Academies Keck Futures Initiative on Synthetic Biology
- National Institutes of Health [GM077596]
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Aryl-aldehydes are a common feature in fungal polyketides, which are considered to be exclusively generated by the R domain of nonreducing polyketide synthases (NR-PKSs). However, by cloning and heterologous expression of both cryptic NR-PKS and nonribosomal peptide synthase (NRPS)-like genes from Aspergillus terreus in Saccharomyces cerevisiae, we identified a distinct mechanism for aryl-aldehyde formation in which a NRPS-like protein activates and reduces an aryl-acid produced by the accompanying NR-PKS to an aryl-aldehyde. Bioinformatics study indicates that such a mechanism may be widely used throughout the fungi kingdom.
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