Journal
CHEMISTRY & BIOLOGY
Volume 20, Issue 3, Pages 316-331Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2013.02.006
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Funding
- Association pour la Recherche curie Cancer (ARC) [3940, SFI20111204054]
- Conectus
- Labex Medalis
- Fondation pour la Recherche Medicale
- MNESR
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Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.
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