Journal
CHEMISTRY & BIOLOGY
Volume 19, Issue 8, Pages 1020-1027Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2012.06.013
Keywords
-
Categories
Funding
- Natural Science and Engineering Research Council of Canada
- Canadian Institutes for Health Research [MOP-57684]
Ask authors/readers for more resources
Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and for many other medicinal applications. The mechanisms that limit the production of these molecules in the laboratory are not well understood, and this has impeded the discovery of many important compounds. We have identified small molecules that remodel the yields of secondary metabolites in many actinomycetes and show that one set of these molecules does so by inhibiting fatty acid biosynthesis. This demonstrates a particularly intimate relationship between this primary metabolic pathway and secondary metabolism and suggests an approach to enhance the yields of metabolites for discovery and biochemical characterization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available