Journal
CHEMISTRY & BIOLOGY
Volume 18, Issue 11, Pages 1499-1512Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2011.08.012
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Funding
- European Union [Eurofung-base LSSG-CT-2005-018964]
- Ministry of Science and Innovation (Madrid) [PTQ06-2-0113]
- Diputacion de Leon (Spain)
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A single gene cluster of Penicillium chrysogenum contains genes involved in the biosynthesis and secretion of the mycotoxins roquefortine C and meleagrin. Five of these genes have been silenced by FINAL Pc21g15480 (rds) encodes a nonribosomal cyclodipeptide synthetase for the biosynthesis of both roquefortine C and meleagrin. Pc21g15430 (rpt) encodes a prenyltransferase also required for the biosynthesis of both mycotoxins. Silencing of Pc21g15460 or Pc21g15470 led to a decrease in roquefortine C and meleagrin, whereas silencing of the methyltransferase gene (Pc21g15440; gmt) resulted in accumulation of glandicolin B, indicating that this enzyme catalyzes the conversion of glandicolin B to meleagrin. All these genes are transcriptionally coregulated. Our results prove that roquefortine C and meleagrin derive from a single pathway.
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