Journal
CHEMISTRY & BIOLOGY
Volume 18, Issue 3, Pages 293-298Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2011.01.013
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Funding
- NIH [GM02278]
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The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 angstrom crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.
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