Journal
CHEMISTRY & BIOLOGY
Volume 18, Issue 7, Pages 833-838Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2011.07.003
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Funding
- National Institutes of Health/NIGMS [R01GM065400, R01 GM095501]
- Howard Hughes Medical Institute
- NIDDK [U01 DK089536]
- Harvard Stem Cell Institute (HSCI)
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We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.
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