Journal
CHEMISTRY & BIOLOGY
Volume 17, Issue 10, Pages 1052-1065Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2010.09.007
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Funding
- National Cancer Institute [U54CA143803]
- Fonds der Chemischen Industrie
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Microfluidic systems are an attractive solution for the miniaturization of biological and chemical assays The typical sample volume can be reduced up to 1 million-fold, and a superb level of spatiotemporal control is possible, facilitating highly parallelized assays with drastically increased throughput and reduced cost In this review, we focus on systems in which multiple reactions are spatially separated by immobilization of reagents on two-dimensional arrays, or by compartmentalization in microfabricated reaction chambers or droplets These systems have manifold applications, and some, such as next-generation sequencing are already starting to transform biology This is likely the first step in a biotechnological transformation comparable to that already brought about by the microprocessor in electronics We discuss both current applications and likely future impacts in areas such as the study of single cells/single organisms and high-hroughput screening
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