Journal
CHEMISTRY & BIOLOGY
Volume 17, Issue 11, Pages 1171-1176Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2010.09.008
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Funding
- Starr Cancer Consortium [I1-A42]
- NIH [R21AI068512]
- National Cancer Institute [T32CA062948]
- Fundacao para a Ciencia e Tecnologia, Portugal
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Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological solutions.
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