Journal
CHEMISTRY & BIOLOGY
Volume 17, Issue 6, Pages 624-632Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2010.05.010
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Funding
- Canada Research Chairs
- Canadian Institutes of Health Research [MOP-15496, MOP-6492, MOP-81330]
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Recent genome-scale analyses of genetic interactions in model microbes have revealed the inherent functional organization of the cell as a dense network of highly interconnected pathways. While classical one gene at a time paradigms offer limited insight into cellular systems, genome-scale approaches are making considerable headway. Indeed, where small organic compounds are ideal probes of biological complexity, systematic chemical genomic methods are emerging as requisite and powerful approaches to describing both the small molecule probe and network with which it interacts. Here, we highlight various chemical genomic approaches that are being pioneered in model microbes.
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