Journal
CHEMISTRY & BIOLOGY
Volume 17, Issue 2, Pages 104-106Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2010.02.003
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Funding
- NHGRI NIH HHS [R21 HG004060, R21 HG004060-03] Funding Source: Medline
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Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics.
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