Journal
CHEMISTRY & BIOLOGY
Volume 16, Issue 8, Pages 801-802Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2009.08.004
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How can an ex-orphan be adopted? is it possible to do so by attributing to it a key endogenous ligand that regulates its central functions? In the recent issue of Cell, Chakravarthy et al. attempted to answer this question by characterizing a new physiologically relevant ligand for the ex-orphan receptor peroxisome proliferator activated receptor alpha (PPAR alpha).
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