Journal
CHEMISTRY & BIOLOGY
Volume 15, Issue 5, Pages 419-421Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2008.04.010
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An article in this issue of Chemistry & Biology (Hines et al., 2008) and a recent study in Nature (Groll et al., 2008) establish three natural products as novel proteasome inhibitors. These inhibitors, discovered in an unusual way, reveal a different mechanism of proteasome inhibition and suggest new therapeutic application of its inhibitors.
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