Journal
CHEMISTRY & BIODIVERSITY
Volume 11, Issue 5, Pages 760-766Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201300154
Keywords
Euphorbia pilosa; Diterpenoids; Daphnane; Glycosides; Cytotoxic activity
Funding
- National Natural Science Funding of China [31170333, 81072543]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2008PY066]
- Academy-Locality Cooperation Project of Chinese Academy of Sciences [XBKM-2011-004]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ02]
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Phytochemical investigation of whole plants of Euphorbia pilosa led to the isolation and identification of two new daphnane-diterpenoid glucosides, euphopilosides A and B (1 and 2, resp.), and a new ent-abietane, euphopilolide (3), together with eight known compounds. Compounds 1 and 2 are the first daphnane-type diterpenoid glycosides. Their structures were elucidated by a combination of 1D- and 2D-NMR, and MS analyses, and acid hydrolysis. Compounds 1-9 were evaluated for their in vitro cytotoxicities against five human tumor cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compound 7 showed moderate inhibitory activity against all five cell lines.
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