4.5 Article

Chemical Composition and Antimicrobial Activity of the Essential Oil of Ruta chalepensis L. Growing Wild in Lebanon

Journal

CHEMISTRY & BIODIVERSITY
Volume 11, Issue 12, Pages 1990-1997

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201400109

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Funding

  1. Agence Nationale de la Recherche, France (CEBA) [ANR-10-LABX-25-01]

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The essential oils (EOs) isolated from the fresh aerial parts of Ruta chalepensis L. collected in North Lebanon were obtained by solvent-free microwave extraction (Milestone (R)), yielding 0.12% EO from both the leaves and a mixture of stems and leaves. The EOs were characterized by GC/MS analysis, and 27 components were identified, which were primarily ketones (88.0-93.2%). The main components were nonan-2-one and undecan-2-one. The antimicrobial activity of the EOs against a Gram-positive and a Gram-negative bacterium, a yeast, and a dermatophyte was evaluated using the broth-microdilution technique and expressed as minimal inhibitory concentration (MIC). The EOs revealed moderate in vitro antifungal activity against Trichophyton rubrum and Candida albicans.

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