Journal
CHEMISTRY & BIODIVERSITY
Volume 10, Issue 6, Pages 1120-1127Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201200144
Keywords
Zephyranthes robusta; Alzheimer's disease; Hippeastidine; Acetylcholinesterase; Butyrylcholinesterase; Inhibitors
Funding
- Charles University [17/2012/UNCE]
- [SVV UK 265 002]
- [FRVS 664/2011]
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The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC50(HuAChE) 28.0 +/- 0.9M).
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