Journal
CHEMISTRY & BIODIVERSITY
Volume 9, Issue 2, Pages 385-393Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100061
Keywords
Piperazine-2; 5-diones; Aspergillus fumigatus; Marine natural products; Fungi; Antiproliferative activity
Funding
- National Natural Science Foundation of China [20872094, 21002064]
- National High Technology Research and Development Program of China (863 Program) [2007AA09Z413]
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Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 614. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC50 values of 1.8, 0.2, and 0.5 mu M, respectively.
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