Journal
CHEMISTRY & BIODIVERSITY
Volume 9, Issue 10, Pages 2195-2202Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100345
Keywords
Melicope denhamii; Melicodenones A?-?E; Sesquiterpenes; Cytotoxic activity
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Two novel zierane-type sesquiterpenes, named melicodenones A and B (1 and 2, resp.), and three new guaiane-type sesquiterpenes, named melicodenones CE (35), were isolated from the root of Melicope denhamii (Seem.) T. G. Hartley together with zierone (6). Their structures were established by extensive NMR-spectroscopic analyses. Compounds 16 were tested for cytotoxicity using human colon cancer DLD-1 cells, and melicodenone A (1) was found to exhibit moderate activity.
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