Journal
CHEMISTRY & BIODIVERSITY
Volume 9, Issue 3, Pages 654-661Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100122
Keywords
Cespitularia taeniata; Verticillane diterpenoids; Diterpenoids; Cespitulins E?-?G; Anti-inflammatory activity; Soft corals
Funding
- National Science Council, Republic of China [NSC-98-2113-M-002-002-MY3]
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Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins EG (13, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.
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