Journal
CHEMISTRY & BIODIVERSITY
Volume 8, Issue 5, Pages 895-901Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbdv.201000134
Keywords
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Funding
- Chinese Ocean Mineral Resource RD Association [DY105-2-04]
- promotive research fund for excellent young and middle-aged scientists of Shandong Province [BS2010HZ027]
- Specialized Research Fund for the Doctoral Program of Higher Education, 'SRFDP' [20100132120026]
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Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5 +/- 1.4, 0.1 +/- 0.1, and 0.2 +/- 0.01 mu M, resp.) and K562 (IC(50) values of 22.9 +/- 0.8, 4.8 +/- 0.3 and 22.4 +/- 0.9 mu M, resp.) cell lines.
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