Journal
CHEMISTRY & BIODIVERSITY
Volume 8, Issue 4, Pages 692-698Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbdv.201000110
Keywords
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Funding
- National Science Foundation of China for Distinguished Young Scholars [81025023]
- Chinese Academy of Sciences [GJHZ200818]
- CAS-Croucher Foundation [CAS-CF07/08.SC03]
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Two new lignans, dihydrodehydrodiconiferyl alcohol 9-O-beta-D-(3 ''-O-acetyl)-xylopyranoside (1) and threo-4,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan 7-O-alpha-rhamnopyranoside (2) were isolated from Illicium henryi, together with ten known compounds, 3-12. Their structures were elucidated by extensive spectroscopic analyses. The anti-hepatitis B virus (anti-HBV) activity of compounds 1-12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (-)-Dihydrodehydrodiconiferyl alcohol (4) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC(50) values of 0.06 and 0.53 mm, respectively.
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