Journal
CHEMISTRY & BIODIVERSITY
Volume 7, Issue 6, Pages 1555-1562Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200900283
Keywords
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Funding
- Korea Research Council of Fundamental Science and Technology
- KRIBB Initiative [KGM3110912]
- Seoul RBD Program [10580]
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Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that gamma-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight gamma-PGA and its various applications in industrial fields.
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