Journal
CHEMISTRY & BIODIVERSITY
Volume 7, Issue 1, Pages 1-59Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200900185
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Starting from pyranose nucleic acids, several series of modified nucleic acids with a six-membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology.
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