Journal
CHEMISTRY & BIODIVERSITY
Volume 5, Issue 9, Pages 1811-1816Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200890170
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Funding
- Foundation for Japanese Chemical Research
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The structures of two new cyathane-type diterpenoids isolated from a liquid culture Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11 alpha.14 alpha-epoxy-13 alpha,14 beta,15-trihydroxycyath-3-ene and (12R)-11 alpha,14 alpha-epoxy-13 alpha,14 beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhihitory activity against YMB and COLO 201 cells.
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