Furanocembranoids from the Soft Corals Sinularia asterolobata and Litophyton arboreum

The new cembranoid diterpene danielid (1) along with 3 alpha-ethoxyfuranocembranoid 2, pukalide (3), 13 alpha-acetoxypukalide (4), furanocembranoid 5, and furanosesquiterpene 6 have been isolated from the soft coral Sinularia asterolobata. The furanocembranoid diterpene 11 beta,12 beta-epoxypukalide (7) and the sesquiterpene (-)-bicyclogermacrene (8) have been obtained from the soft coral Litophyton arboreum. The structures were elucidated primarily by NMR spectroscopy. The furanocembranoids 2,41, and 5 show good antiproliferative activities against the cell lines L-929 and K-562, and weak cytotoxic effects on HeLa cells.