Journal
CHEMIE INGENIEUR TECHNIK
Volume 85, Issue 1-2, Pages 103-110Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cite.201200175
Keywords
Automated cell culture; Cell therapy; Centrifugation chamber; Clinical cell processing; Density gradient separation; Magnetic cell separation; Tubing set
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Funding
- German Federal Ministry of Education and Research [0312138B]
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Manufacturing of cellular products for therapeutic purposes like stem cell or cancer therapy requires equipment with specific characteristics not always addressed by conventional technologies. A new integrated cell processing device is presented that can handle all current technical requirements for manufacturing cellular products by automation of the complete process in a GMP-compliant single-use tubing set. Its capabilities are exemplified in the presented study by successful processing of adult stem cells, natural killer cells, and several cell lines. Multiple cell processing workflows can be automated in a functionally closed environment: from cell separation through cell culture to formulation of the final product.
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