Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 218, Issue -, Pages 82-88Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2014.05.001
Keywords
ARNT; Crosstalk; Environmental toxicants; Metabolism; Oxygen sensing
Funding
- National Institutes of Health (NIH) [P42 ES013661-5099]
- Superfund Research Program Training Core [P42 ES013661-5110]
Ask authors/readers for more resources
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. To regulate gene expression, the AhR requires its binding partner, the aryl hydrocarbon receptor nuclear translocator (ARNT). ARNT is also required by the hypoxia-inducible factor-1 alpha (HIF-1 alpha), a crucial regulator of responses to conditions of reduced oxygen. The important role of ARNT in both the AhR and HIF-1 alpha signaling pathways establishes a meaningful foundation for a possible crosstalk between these two vitally important signaling pathways. This crosstalk might lead to interference between the two signaling pathways and thus might play a role in the variety of cellular responses after exposure to AhR ligands and reduced oxygen availability. This review focuses on studies that have analyzed the effect of low oxygen environments and hypoxia-mimetic agents on AhR signaling and conversely, the effect of AhR ligands, with a special emphasis on PCBs, on HIF-1 alpha signaling. We highlight studies that assess the role of ARNT, elucidate the mechanism of the crosstalk, and discuss the physiological implications for exposure to AhR-inducing compounds in the context of hypoxia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available