Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 202, Issue 1-3, Pages 283-287Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2012.12.001
Keywords
Aldose reductase; BGG; Macrophage; LPS; ROS; Uveitis
Funding
- NIH [EY005856, EY021498]
- ARVO Foundation for Eye Research (Bethesda, MD)
Ask authors/readers for more resources
Aldose reductase (AR) catalyzes the reduction of toxic lipid aldehydes to their alcohol products and mediates inflammatory signals triggered by lipopolysaccharide (LPS). Beta-glucogallin (BGG), a recently described AR inhibitor, was purified from extracts of the Indian gooseberry (Emblica officinalis). In this study, we found that BGG showed low cytotoxicity in Raw264.7 murine macrophages and effectively inhibited AR activity as measured by a decrease in sorbitol accumulation. In addition, BGG-mediated inhibition of AR prevented LPS-induced activation of JNK and p38 and lowered ROS levels, which could inhibit LPS-induced apoptosis. Uveitis is a disease of the eye associated with chronic inflammation. In this study, we also demonstrated that treatment with BGG decreased the number of inflammatory cells that infiltrate the ocular media of mice with experimental uveitis. Accordingly, these results suggest BGG is a potential therapy for inflammatory diseases. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available