Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 192, Issue 1-2, Pages 113-117Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2010.11.003
Keywords
Histone modifications; Mass spectrometry; Quantitation; Arsenic toxicity; Histone acetyltransferase
Funding
- NCRR NIH HHS [P41 RR001614] Funding Source: Medline
- NIEHS NIH HHS [P42 ES004705] Funding Source: Medline
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Recent studies reveal that posttranslational modifications on chromatin proteins, especially histones, organize genomic DNA and mediate various cellular responses to environmental influences. Quantitative mass spectrometric analysis is a powerful approach to reveal these dynamic events on chromatin in a systematic manner. Here, the effects of arsenic exposure on histone epigenetic state were investigated in human UROtsa cells, and a reduction in acetylation level on several histone H3 and H4 lysine residues was detected. Furthermore, MYST1 was shown to be the major histone acetyltransferase for H4 Lys16 and protect UROtsa cells from arsenic toxicity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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