Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 191, Issue 1-3, Pages 38-41Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2010.12.007
Keywords
Alcohol dehydrogenase 1B; Alcoholism; Polymorphism; SNP; Promoter; Gene expression; Haplotype
Funding
- National Institute on Alcohol Abuse and Alcoholism, NIH [R37AA006460]
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The primary pathway of metabolism of dietary alcohol is via its oxidation in liver by alcohol dehydrogenases (ADH). Differences in the ADH enzyme activity or levels of enzyme present could affect the risk for alcoholism. Regulatory variations have been shown to affect the promoter activity and thereby affect the risk for alcoholism. In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored. We examined the effects of five naturally occurring haplotypes on the promoter activity. We observed that a C to A change at rs1229982 increased promoter activity 1.4-fold. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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