Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 187, Issue 1-3, Pages 421-424Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2010.02.036
Keywords
Cocaine hydrolase; Butyrylcholinesterase; Cocaine vaccine; Anti-cocaine-antibody
Funding
- NIDA NIH HHS [R01 DA023979, R01 DA030338, R01 DA23979Z-03S1, R01 DA023979-03S1] Funding Source: Medline
Ask authors/readers for more resources
Cocaine access to brain tissue and associated cocaine-induced behaviors are substantially reduced in rats and mice by significant plasma levels of an enzyme that rapidly metabolizes the drug. Similar results have been obtained in rodents and humans with therapeutic anti-cocaine antibodies, which sequester the drug and prevent its entry into the brain. We show that an efficient cocaine hydrolase can lead to rapid unloading of anti-cocaine antibodies saturated with cocaine, and we provide a theoretical basis for the hypothesis that dual therapy with antibody and hydrolase enzyme may be especially effective. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available