Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 181, Issue 3, Pages 316-321Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2009.06.022
Keywords
Zn(II)-curcumin complex; Antiulcer; NF-kappa B; TGF-beta(1); IL-8; Synergistic effect
Funding
- National Natural Science Foundation of China
- Program of New Century Excellent Talent of China [NCET-04-0808]
- Program of the Fok Ying Tung Education Foundation of China [91036]
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Zn(II)-curcumin, a mononuclear (1:1) zinc complex of curcumin was synthesized and examined for its antiulcer activities against pylorus-ligature-induced gastric ulcer in rats. The structure of Zn(II)-curcumin was identified by elemental analysis, NMR and TG-DTA analysis. It was found that a zinc atom was coordinated through the keto-enol group of curcumin along with one acetate group and one water molecule. Zn(II)-curcumin (12, 24 and 48 mg/kg) dose-dependently blocked gastric lesions, significantly reduced gastric volume, free acidity, total acidity and pepsin, compared with control group (P<0.001) and curcumin alone (24 mg/kg, P<0.05). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed that Zn(II)-curcumin markedly inhibited the induction of nuclear factor-kappa B (NF-kappa B). transforming growth factor beta(1) (TGF-beta(1)) and interleukin-8 (IL-8), compared with control group (P<0.05). These findings suggested that Zn(II)-curcumin prevented pylorus-ligation-induced lesions in rat by inhibiting NF-kappa B activation and the subsequent production of proinflammatory cytokines, indicating a synergistic effect between curcumin and zinc. An acute toxicity study showed that mice treated with SDs of Zn(II)-curcumin (2 g/kg) manifested no abnormal signs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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